Neuropsychology
Dr Nicholas I. Bradfield
MD DPsych
Research
Publications
Bradfield NI, Ellis KA, Savage G, Maruff P, Burnham S, Darby D, Lautenschlager NT, Martins RN, Masters CL, Rainey-Smith SR, Robertson J, Rowe C, Woodward M, Ames D (2018) Baseline amnestic severity predicts progression from mild cognitive impairment to Alzheimer’s disease dementia at 3 years. Alzheimer’s Disease and Associated Disorders (In press)
Bradfield NI, McLean C, Drago J, Darby DG, Ames D (2017). Rapidly progressive Fronto-temporal dementia (FTD) associated with Frontotemporal lobar degeneration (FTLD) in the presence of Fused in Sarcoma (FUS) protein: a rare, apparently sporadic but aggressive form of FTD. International Psychogeriatrics 29(10) 1743-1746. pdf
Iansek R, Danoudis M, Bradfield NI (2013). Gait and cognition in Parkinson’s disease: Implications for rehabilitation. Reviews in the Neurosciences 24(3): 293–300. pdf
Bradfield NI, Reutens DC, Chen J, Wood AG (2012). Stereotaxic localisation of the dorsolateral prefrontal cortex for transcranial magnetic stimulation is superior to the standard reference position. Australian and New Zealand Journal of Psychiatry 46(3): 232-239. pdf
Bradfield NI (2009) Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex: Effects on mood and functional connectivity. Monash University: Melbourne link
Bradfield NI, Reutens DC, Chen J, Wood AG (2008). Resting state functional connectivity of the dorsolateral prefrontal cortex: Laterality effects. Neuroimage 41(S1):S176. pdf
Bradfield NI, McLean C, Drago J, Darby DG, Ames D (2017). Rapidly progressive Fronto-temporal dementia (FTD) associated with Frontotemporal lobar degeneration (FTLD) in the presence of Fused in Sarcoma (FUS) protein: a rare, apparently sporadic but aggressive form of FTD. International Psychogeriatrics 29(10) 1743-1746. pdf
Iansek R, Danoudis M, Bradfield NI (2013). Gait and cognition in Parkinson’s disease: Implications for rehabilitation. Reviews in the Neurosciences 24(3): 293–300. pdf
Bradfield NI, Reutens DC, Chen J, Wood AG (2012). Stereotaxic localisation of the dorsolateral prefrontal cortex for transcranial magnetic stimulation is superior to the standard reference position. Australian and New Zealand Journal of Psychiatry 46(3): 232-239. pdf
Bradfield NI (2009) Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex: Effects on mood and functional connectivity. Monash University: Melbourne link
Bradfield NI, Reutens DC, Chen J, Wood AG (2008). Resting state functional connectivity of the dorsolateral prefrontal cortex: Laterality effects. Neuroimage 41(S1):S176. pdf
Conference Presentations
2017 NHMRC National Institute for Dementia Research Australian Dementia Forum poster
“Baseline amnestic severity in mild cognitive impairment predicts incident Alzheimer’s disease dementia at 3 years”
2017 Aikenhead Centre for Medical Discovery Research Week poster
“Cognition predicts progression from mild cognitive impairment to dementia due to Alzheimer’s disease”
2017 The University of Melbourne MD Student Conference poster
“Severity of memory impairment in mild cognitive impairment predicts progression to Alzheimer’s dementia at 3 years”
2008 Organisation for Human Brain Mapping Meeting abstract and poster
“Resting state functional connectivity of the DLPFC: Laterality effects:
“Baseline amnestic severity in mild cognitive impairment predicts incident Alzheimer’s disease dementia at 3 years”
2017 Aikenhead Centre for Medical Discovery Research Week poster
“Cognition predicts progression from mild cognitive impairment to dementia due to Alzheimer’s disease”
2017 The University of Melbourne MD Student Conference poster
“Severity of memory impairment in mild cognitive impairment predicts progression to Alzheimer’s dementia at 3 years”
2008 Organisation for Human Brain Mapping Meeting abstract and poster
“Resting state functional connectivity of the DLPFC: Laterality effects:
Other
2017: Invited reviewer for International Psychogeriatrics
2014: Invited reviewer for Journal of the International Neuropsychological Society
2012: Invited reviewer for Australian and New Zealand Journal of Psychiatry
2014: Invited reviewer for Journal of the International Neuropsychological Society
2012: Invited reviewer for Australian and New Zealand Journal of Psychiatry
Research Projects
2017 The Florey Institute of Neuroscience and Mental Health
Completed a 6-month research project with Prof David Ames on the Australian Imaging, Biomarker & Lifestyle Study of Ageing (AIBL) looking at mild cognitive impairment and Alzheimer’s disease as part of the Doctor of Medicine program.
2009 Department of Neurosciences, Monash Medical Centre
Conducted research into the functional connectivity of the dorsolateral prefrontal cortex using functional Magnetic Resonance Imaging, its relation to mood and its modulation by repetitive transcranial magnetic stimulation. Also constructed a probabilistic atlas of the lateral prefrontal gyri.
2008 National Trauma Research Institute, Alfred Hospital
Recruited mild head injury patients and controls from the Emergency Department of the Alfred Hospital. Monitored patients coming out of post-traumatic amnesia, and conducted baseline and follow up assessments of cognition and functional status. Validated an hourly version of the Westmead Post Traumatic Amnesia Scale.
2007 School of Psychology, Psychiatry and Psychological Medicine, Monash University
Conducted cognitive assessments of participants with mild to severe dementia for a study examining the effects of diversional therapies on memory functioning.
2006 Department of Neurosciences, Monash Medical Centre
Manually segmented a variety of lesions acquired through traumatic brain injury as visualised on a range of differently weighted Magnetic Resonance Images.
2002 Centre for Applied Drug and Alcohol Research
Researched and collated data on governmental drug policies on prevention and harm minimisation of illicit substance use.
2002 Integrative Neuroscience Laboratory, Monash University
Honours project explored the role of beta-amyloid in Alzheimer’s disease. Showed that treatment with β amyloid did not affect the viability of cultured astrocytes, even after β amyloid was chelated with iron.
2001 Centre for Applied Drug and Alcohol Research, Monash University
Applied the Crime Prevention Through Environmental Design principles to determine whether the environmental design of public places was associated with the level of drug use seen at the site through observation of direct and indirect drug litter.
2000 Integrative Neuroscience Laboratory, Monash University
Upon observation that glutathione peroxidase (GPx) transgenic mice were susceptible to a larger infarct volume following ischaemic stroke, we found that iron was stored in neurons rather than in oligodendrocytes in GPx transgenic mice’s brains.
Completed a 6-month research project with Prof David Ames on the Australian Imaging, Biomarker & Lifestyle Study of Ageing (AIBL) looking at mild cognitive impairment and Alzheimer’s disease as part of the Doctor of Medicine program.
2009 Department of Neurosciences, Monash Medical Centre
Conducted research into the functional connectivity of the dorsolateral prefrontal cortex using functional Magnetic Resonance Imaging, its relation to mood and its modulation by repetitive transcranial magnetic stimulation. Also constructed a probabilistic atlas of the lateral prefrontal gyri.
2008 National Trauma Research Institute, Alfred Hospital
Recruited mild head injury patients and controls from the Emergency Department of the Alfred Hospital. Monitored patients coming out of post-traumatic amnesia, and conducted baseline and follow up assessments of cognition and functional status. Validated an hourly version of the Westmead Post Traumatic Amnesia Scale.
2007 School of Psychology, Psychiatry and Psychological Medicine, Monash University
Conducted cognitive assessments of participants with mild to severe dementia for a study examining the effects of diversional therapies on memory functioning.
2006 Department of Neurosciences, Monash Medical Centre
Manually segmented a variety of lesions acquired through traumatic brain injury as visualised on a range of differently weighted Magnetic Resonance Images.
2002 Centre for Applied Drug and Alcohol Research
Researched and collated data on governmental drug policies on prevention and harm minimisation of illicit substance use.
2002 Integrative Neuroscience Laboratory, Monash University
Honours project explored the role of beta-amyloid in Alzheimer’s disease. Showed that treatment with β amyloid did not affect the viability of cultured astrocytes, even after β amyloid was chelated with iron.
2001 Centre for Applied Drug and Alcohol Research, Monash University
Applied the Crime Prevention Through Environmental Design principles to determine whether the environmental design of public places was associated with the level of drug use seen at the site through observation of direct and indirect drug litter.
2000 Integrative Neuroscience Laboratory, Monash University
Upon observation that glutathione peroxidase (GPx) transgenic mice were susceptible to a larger infarct volume following ischaemic stroke, we found that iron was stored in neurons rather than in oligodendrocytes in GPx transgenic mice’s brains.
